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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED13L All Species: 15.76
Human Site: S445 Identified Species: 28.89
UniProt: Q71F56 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q71F56 NP_056150.1 2210 242602 S445 P N R P P T V S Q P G F S A G
Chimpanzee Pan troglodytes XP_001138050 2188 240763 S448 L R H K N L K S R N A G Q Q G
Rhesus Macaque Macaca mulatta XP_001112106 2210 242628 S445 P N R P P T M S Q P G F S A G
Dog Lupus familis XP_534693 2280 250152 S515 P N R P P A I S Q P G F S A G
Cat Felis silvestris
Mouse Mus musculus Q6JPI3 2207 241740 S440 P S R P P A I S Q P G F S A G
Rat Rattus norvegicus NP_001101807 1374 149708
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509907 2170 238695 P430 S R H K N L K P R N S G Q Q G
Chicken Gallus gallus XP_415317 2195 241321 N425 S S R P P M I N Q P G F S V G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A2VCZ5 2102 230974 K392 N R A Q N K R K F S T M S N G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KTX8 2618 280005 S587 A S T Y S R N S L G G D S S M
Honey Bee Apis mellifera XP_393643 1982 216109 Y295 V G G V R M R Y P S C Y V L V
Nematode Worm Caenorhab. elegans Q93442 2862 325119 E757 M S R A E K I E H A H Y Q F D
Sea Urchin Strong. purpuratus XP_001203054 1127 123639
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.7 99.2 93.3 N.A. 92.4 57.7 N.A. 53.5 86.4 N.A. 50.2 N.A. 24.8 33.9 21.2 25.6
Protein Similarity: 100 69.3 99.6 94.7 N.A. 95.7 59.9 N.A. 69.7 92.5 N.A. 66.4 N.A. 41.5 50.5 38.5 35.1
P-Site Identity: 100 13.3 93.3 86.6 N.A. 80 0 N.A. 6.6 60 N.A. 13.3 N.A. 20 0 6.6 0
P-Site Similarity: 100 20 100 93.3 N.A. 93.3 0 N.A. 13.3 80 N.A. 13.3 N.A. 33.3 6.6 26.6 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 8 0 16 0 0 0 8 8 0 0 31 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % D
% Glu: 0 0 0 0 8 0 0 8 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 39 0 8 0 % F
% Gly: 0 8 8 0 0 0 0 0 0 8 47 16 0 0 62 % G
% His: 0 0 16 0 0 0 0 0 8 0 8 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 31 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 16 0 16 16 8 0 0 0 0 0 0 0 % K
% Leu: 8 0 0 0 0 16 0 0 8 0 0 0 0 8 0 % L
% Met: 8 0 0 0 0 16 8 0 0 0 0 8 0 0 8 % M
% Asn: 8 24 0 0 24 0 8 8 0 16 0 0 0 8 0 % N
% Pro: 31 0 0 39 39 0 0 8 8 39 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 39 0 0 0 24 16 0 % Q
% Arg: 0 24 47 0 8 8 16 0 16 0 0 0 0 0 0 % R
% Ser: 16 31 0 0 8 0 0 47 0 16 8 0 54 8 0 % S
% Thr: 0 0 8 0 0 16 0 0 0 0 8 0 0 0 0 % T
% Val: 8 0 0 8 0 0 8 0 0 0 0 0 8 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 8 0 0 0 16 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _